More Efficient Together
Biologically active food supplement
Everyday defence against stress
Take It Easy!
Biologically active food supplement Pax+Forte anti-stress, calming, sedative, antispasmodic, anticonvulsant complex. It strengthens the nervous system, normalizes sleep, reduces the effects of stress, normalize digestion process.
Pax+ forte is a powerful anti-stress complex that protects every cell of the body from the disruptive impact of stress. Enhanced by the “elements of calmness”— magnesium and vitamin B6, it alleviates anxieties and discomfort, reduces excessive nervousness and excitability, improves stress-resistance. It promotes the feeling of calmness without reducing the working capacities and blunting reactions. Makes up for deficiency of vitamins and minerals that are quickly burnt by the stress.
The ingredients in the Pax+Forte biologically active food supplement make up for a deficiency of vitamins, minerals, and other biologically active substances in one’s diet and enhances body tolerance to stress situations. Stress and stress-related disorders are a significant cause of disease in modern man, contributing to perhaps 75%of all illnesses. Pax+Forte improves and strengthens the nervous system, helps to deal with stress. It is an anti-stress combination that calms and normalizes the nervous system.
|All components of Pax+Forte are selected so that they not only fill a shortage of the named substances in a ration, but also normalize functions of the nerves the most part of the population needs to. Because of carefully adjusted and science-based proportions of the components of the product, it takes gentle assuaging effect and makes for general relaxation of organism and sleep improvement. That is exactly why this phyto-mineral-vitamin complex is very necessary for people during heavy stress and psycho-emotional assignment, vigilance and heightened nervous irritability.|
Natural Supplement contains medicinal herbs which are used for insomnia, nervous disorders, hysteria, anxiety, depression, convulsions, and sleep disorders.
MELISSA, VALERIANA AND LAVENDER contain selenium, have an anti-anxiety, anti-spasmodic, hypotensive, anaesthetic, antimicrobial, antihistaminic, cardio-boosting, and diuretic effect. They are effective calming and stressrelieving remedies against hypertension, tachycardia, bronchial allergy, depression, nerve strains, migraine, insomnia, menstrual pains, and digestion disorders.
VITAMINS OF THE GROUP B support the body during emotional strains, strengthen memory, improve sleep, and alleviate stress after-effects. MAGNESIUM is an anti-stress macro-element that restores the central nervous system. CALCIUM regulates the functioning of the central nervous system in case of deficiencies of parathyroid glands or allergies.
The main directions of the regulatory action organic supplement:
- Overall strengthening
- Pax+ Forte is an anti-stress, general restorative, sedative, antispasmodic and anticonvulsant complex, which normalizes the nervous system.
- Relieves muscle tension and promotes rapid recovery of the body.
- It has a calming effect. A feeling of tranquility after the stress does not reduce efficiency, no dulling of the reaction.
- Regulate the functioning of the nervous system. Produces a mild relaxing effect on the central nervous system.
- Improves body resistibility to stress. Neutralizes the consequences of stressful situations.
- Alleviates anxiety and discomfort, reduces excessive nervousness, depression and excitability.
- Promotes concentration, improves mood.
- Normalize sleep.
- Support the functioning of the cardio-vascular system.
- It is recommended for students during exams, drivers and people in need of increased attention.
- Very rezultativen in stuttering and enuresis in children.
- Provides analgesic effect.
- Helps with skin diseases.
- Improves the condition of the heart and blood vessels. Has a beneficial regulatory influence on heart performance and normalizes cardiac rhythm.
- Help eliminate allergic reactions.
- Normalizes digestion.
- Potentiates (enhances) the effects of other drugs (BAA).
- Effective in:
- hypertension (high blood pressure when), vascular spasm in the brain to prevent strokes and heart attacks, heart rhythm disturbances (tachycardia and fibrillation);
- depression, nervous stress, insomnia,
- migraine, painful periods,
- problems of the gastrointestinal tract (ulcers of 12 duodenal ulcer and stomach, gastritis, pancreatitis, hepatitis, etc.), the liver and biliary tract;
- painful sensations of internal organs;
- respiratory disease (bronchitis, pneumonia, etc);
- allergic diseases (acute allergic Renita, alergozy respiratory tract, bronchial asthma, atopic dermatitis, psoriasis, eczema, hives, etc.);
- diseases of the musculoskeletal system (arthritis, bursitis, osteoarthritis, osteochondrosis, etc.);
- diseases of the genitourinary system (nephritis, pielity, cystitis, urolithiasis, prostatitis, adenoma, etc.);
Target audience to take Pax+ forte:
- Those prone to stress situations;
- People who experience extensive emotional loads;
- Those with feeble nervous and cardiovascular systems;
- Those who frequently experience feelings of anxiety and discomfort;
- Those who take care of their health, but due to high emotional strains, anxieties, worries, and seasonal affective disorders need a complex that increases body stress-resistance at least twice a year: in autumn and spring.
Advantages Pax+ Forte:
- Pax+ forte prevents stresses from destroying cells;
- Unlike most calming remedies, Pax+ forte doesn’t in the least blunt the reactions and doesn’t produce a suppressant action, but improves attention focusing instead;
- Makes up for deficiency of vitamins and minerals that are quickly burnt by stress, and primarily of the “elements of calmness”—magnesium and vitamin B6—whose deficiency might cause cramps, spasms, nervousness, broken feeling, pressure upswings and arrhythmia;
- Combination of all necessary vitamins of the group B ensures complete assimilation of plant components and microelements and most effectively influences the nervous and cardiovascular systems.
Ingredients Each capsule contains:
- Lemon Balm — 50 mg
- Lavender — 50 mg
- Valerian root — 50 mg
- Magnesium — 26.02 mg
- Calcium — 24.75 mg
- Vitamin PP — 17.82 mg
- Vitamin B5 — 6.02 mg
- Vitamin B6 — 1.63 mg
- Vitamin B2 — 1.62 mg
- Vitamin B1 — 1.12 mg
- Vitamin B9 — 0.2 mg
- Vitamin H (Biotin) — 0.12 mg
- Vitamin B12 — 1.01 µg
Packaging: 60 capsules 405 mg each.
Recommended as a biologically active food supplement, an additional source of vitamins РР, В1, В2, В6, В9, В12, pantothenic acid, and biotin.
Contraindications: High sensitivity to the ingredients of the preparation, pregnancy, lactation period.
Recommendations for use: Recommended for adults to take 1 capsule per day during meals with water.
Storage conditions: Keep at room temperature (not exceeding 250C) in a dry place out of reach of children.
Shelf life: 3 years.
Manufacturer: «Laboratoires Arkopharma», Z.I. de Carros BP 28-06511 CARROS Cedex France.
There is nothing unusual about stress. In one way or another, everybody experiences stress from time to time. Many Western scientists tend to attribute up to 70% of all diseases to stress. Europe alone loses more than a million people annually because of cardio-vascular system disorders caused by stressful situations. According to specialists, any event that causes a very emotional reaction can result in stress. Bear in mind however, that not only negative emotions, such as loss of work or death of a close person, can provoke stress, but the happiest events as well—for example, a wedding, winning a lottery, birth of a child. Stress can be provoked even by the slightest reason, like rush hour in the subway, or a traffic jam, which are not rare in a big city. Main signs of stress are depression, insomnia and headaches. Long-lasting stress can result in increased blood pressure, diabetes or impotency. Stress affects our behavior, working capacities, health, relations with other people and relatives. How can one help their nervous system if there is no possibility to lead a calm and steady life without any worries?
Pax+ forte food supplement is recommended to normalize sleep and increase the body’s resistibility to stressful situations. It also helps to alleviate anxieties and discomfort, regulates the functioning of the nervous and cardio-vascular systems. Skillfully verified combination of ingredients has been meant to give excellent results. Lavender, valeriana and melissa in Pax+ forte food supplement are commonly used to increase resistibility under strenuous conditions, to help relieve anxiety and prevent stress. Apart from that, this food supplement contains vitamins of the group B that play an important part in the functioning of the nervous system. They support the body during high emotional strains, strengthen memory and help to avoid negative impact of stressful situations. They are involved in hematopoietic process, support the functioning of the urogenital system, as well as the eyesight and the respiratory system.
PROPERTIES OF THE COMPONENTS Pax+ Forte
Lemon Balm (Melissa officinalis L. )
The plant has sedative, antispasmodic, hypotensive, analgesic, antimicrobial andantihistamine effects. Concentrates selenium. Reception Melissa is effective inhypertension, tachycardia, asthma, depression, nervous stress, migraines, insomnia, painful menstruation, as a means of normalizing the digestive processes.
Lavender (Lavandula angustifolia miller)
English lavender (lavandula angustifolia miller) contains volatile oils that reduce anxiety, tension, agitation, and nervousness. Lavender has a sedative, antispasmodic, diuretic and antimicrobial action, is effective in hypertension, neurasthenia, migraine headaches, tachycardia, as wellas a mild sedative. It is used to relieve nervous tension and anxiety, promotesoverall relaxation, normalize digestion.
Valerian (Valeriana officinalis)
The therapeutic effect is inherent in the entire range of plant materials. Valerian has a sedative, tranquilizing, antispasmodic, anticonvulsant activity, has a positive regulatory effect on the heart, including the mechanisms of automaticity and its conducting system, improves coronary circulation and helps reduce blood pressure.
It has a hypnotic effect, improves sleep quality, including patients suffering from insomnia and excitement, does not cause morning drowsiness feeling. Stimulates the secretion and secretory function of the stomach and pancreas.
It is used for nervous agitation, insomnia, migraine, neurasthenia, psychasthenia, vegetonevrozah, diseases of the cardiovascular system, leading to spasms of the coronary arteries, and tachycardia, menopausal disorders, bronchial asthma, neurodermatitis, thyrotoxicosis. Used in conjunction with other sedatives to treat liver diseases, spastic conditions of the gastrointestinal tract.
Thiamine works with the other B vitamins to change protein, carbohydrate, and fat to energy. It is especially vital for changing carbohydrates to energy. It is a key factor in the healthy functioning of all the body’s cells, especially the nerves.
Vitamin B1 helps the body cells convert carbohydrates into energy. It is also essential for the functioning of the heart, muscles, and nervous system. As a coenzyme, thiamin plays a key role in energy production, conversion of glucose to fat. Every cell of the body requires vitamin B1 to form the fuel the body runs on — ATP. Nerve cells require vitamin B1 in order to function normally.
Thiamin is needed for the metabolism of carbohydrates, fat, and protein. It is especially involved in carbohydrate metabolism in the brain.
Thiamin may be used to support nerve health, and minimize numbness and tingling, helping to protect against this condition. Thiamine aids the nervous system and is essential for the functioning of important enzymes. These enzymes have vital roles in the processes that make energy available in the body. Thiamine is essential for the transmission of certain types of nerve signal between the brain and the spinal cord. Depression, poor memory, muscle weakness and stiffness, nerve tingling, burning sensation and numbness, tiredness, headache, loss of appetite and nausea are some of the symptoms and signs of its deficiency.
Riboflavin is an integral component of the coenzymes that participate in many energy-yielding metabolic pathways. Like its close relative vitamin B1 (thiamine), riboflavin plays a crucial role in certain metabolic reactions, particularly the conversion of carbohydrates into sugar, which is «burned» to produce energy. They promote the first steps in the metabolism (breakdown and production) of glucose and of fatty acids. The metabolism of some vitamins and minerals also require riboflavin. Riboflavin is essential for tissue respiration and the generation of energy from the carbohydrates, acids and fats. It is important for body growth and red blood cell production and helps in releasing energy from carbohydrates.
Vitamin B2 helps prevent and is used to treat migraine headaches, cataracts, rheumatoid arthritis, and a number of skin disorders such as acne (acne rosacea), dermatitis, and eczema. In the treatment of anemia, adding Vitamin B2 to iron supplements has shown to increase its effectiveness. Vital to maintaining a proper metabolism, riboflavin also helps to shore up the immune system by reinforcing antibody reserves, the body’s first line of defense against infection. Along with iron, riboflavin is essential for producing the red blood cells that carry oxygen throughout the body. In addition, the body uses extra riboflavin to keep tissue in good repair and speed healing of wounds, burns and other injuries.
Along with such B vitamins as vitamin B6 and niacin (which it helps the body convert into active forms), riboflavin protects the nervous system. It may therefore have a role to play in treating nervous system conditions such as numbness and tingling, Alzheimer’s disease, epilepsy, multiple sclerosis, and even anxiety, stress, and fatigue. Carpal tunnel syndrome may benefit from a treatment program including this vitamin when combined with vitamin B6. The body needs vitamin B2 for reproduction and it also enhances the immune system’s ability to fight disease.
Riboflavin is vital for normal reproduction, growth, repair and development of body tissues including the skin, hair, nails, connective tissue and immune system. Riboflavin (vitamin B2) works with the other B vitamins. Dietary and supplemental vitamin B2, along with other nutrients is important for normal vision and prevention of cataracts. Riboflavin’s ability to improve the skin’s secretion of mucus may aid in clearing up skin pustules associated with rosacea.
Vitamin B5 is essential for human growth, reproduction and many normal bodily processes. Vitamin B5 helps metabolize nutrients, manufacture antibodies and produce vitamin D. It also stimulates the healing of wounds. Pantothenic acid is involved in a number of biological reactions, including the production of energy, the catabolism of fatty acids and amino acids, the synthesis of fatty acids, lipids, cholesterol and steroid hormones, and the production of both coenzyme A, and the cellular antioxidant glutathione.
Vitamin B5 is critical to the manufacture of red blood cells as well as sex and stress-related hormones produced in the adrenal glands (small glands that sit atop of the kidneys). Supplements are sometimes used to treat symptoms of allergy and a wide range of skin conditions.
Pantothenic acid is used in the breakdown of carbohydrates, lipids and some amino acids and is also used in the synthesis of coenzyme A. It is the most important component of coenzyme A, which assists in several metabolic pathways and is necessary for the transfer of fats to and from cells. Without it, fats could not be metabolized to energy. These processes include the metabolism of carbohydrates and proteins, the production of glucose in the body, the breakdown of fats and the production of cholesterol and certain hormones. Pantothenic acid plays a role in the synthesis of hemoglobin, steroid hormones, neurotransmitters, and lipids.
Vitamin B5 is important in maintaining a healthy digestive tract and it helps the body use other vitamins more effectively. Pantothenic acid may help to manage stress from psychological strain, migraines, chronic fatigue syndrome, and smoking and alcohol cessation. Pantothenic acid has long been known to be essential for consistent antibody production, for the production of diphtheria toxoid and hemagglutinating antibodies, and for vaccinations against tetanus, typhoid, or Asian influenza. Adding calcium-D-pantothenate to cultured human skin cells given an artificial wound increased the number of migrating skin cells and their speed of migration, effects likely to accelerate wound healing. The body converts pantothenic acid into a chemical called pantethine. When taken as a supplement, pantethine appears to lower the amount of lipids in the blood. A person with high cholesterol may see their level of total of cholesterol—including LDL («bad») cholesterol—while at the same time increasing HDL («good») cholesterol levels.
Vitamin B6 supports more vital bodily functions than any other vitamin. Vitamin B6 is a coenzyme for several enzyme systems. Vitamin B6, used mainly in the body for the processing of amino acids, performs this task along with certain enzymes. It is vital in the metabolism of amino acids in the intestines. It allows the amino acids to be synthesized, broken down and absorbed. The forming of histamine, serotonin, dopamine and adrenaline are dependent on vitamin B6. Vitamin B6 is required for the production of serotonin and helps to maintain healthy immune system functions, to protect the heart from cholesterol deposits, and to prevent kidney stone formation.
Vitamin B6 is indicated for the treatment of sideroblast anemia, neurologic disturbances, seborrhoeic dermatitis, and cheilosis. In combination with folic acid and vitamin B12, vitamin B6 lowers homocysteine levels which is an amino acid linked to heart disease and stroke, and possibly other diseases as well, such as osteoporosis, and Alzheimer’s disease.
Pyridoxine is required for the balancing of hormonal changes in women as well as assisting the immune system and the growth of new cells. Vitamin B6 may be helpful in some women with premenstrual dysphoric disorder, also known as premenstrual syndrome (PMS), and may be useful in some cases of gestational diabetes and for protection against metabolic imbalances associated with the use of some oral contraceptives. Vitamin B6 promotes iron excretion and this has been used as a rationale for treatment in iron storage diseases.
Folic acid plays an essential role in human growth and development, in particular cell division and DNA synthesis. Folic acid is involved in every bodily function that requires cell division. Folic acid works along with vitamin B12 and vitamin C to help the body digest and utilize proteins and to synthesize new proteins when they are needed. Folic acid is important for any stage of human life which involves growth such as pregnancy, lactation and early growth because of the role the folate plays in DNA, RNA and protein production.
Folic acid is indicated for the prevention of some birth defects and appears to confer significant protection against cardiovascular disease and some forms of cancer. Folic acid may be used in the treatment of disorders associated with folic acid deficiency and may also be part of the recommended treatment for certain menstrual problems and leg ulcers. Folic acid also helps with tissue growth and cell function. In addition, it helps to increase appetite when needed and stimulates the formation of digestive acids.
Pregnant women have an increased need for folic acid, both for themselves and their child. Folic acid also is crucial to support the rapid growth of the placenta and fetus. Taken as part of a B-complex vitamin that contains biotin and vitamin B12, folic acid can strengthen the reproductive system in women having trouble conceiving. Without adequate amounts of folic acid, cell division could be impaired, possibly leading to poor growth in the fetus or placenta. Adequate intake of folic acid is vital for the prevention of several types of birth defects, particularly neural tube defects.
Folic acid appears to regulate the body’s production and use of homocysteine. High levels of a substance called homocysteine in the blood is considered to be a risk factor for heart disease. People who are at high risk of strokes and heart disease may greatly benefit by taking folic acid supplements. High levels of homocysteine have also been found to contribute to problems with osteoporosis. Folic acid, together with vitamins B6 and B12, helps break down homocysteine, and may help reverse the problems associated with elevated levels.
Folate status is associated with colorectal, lung, esophageal, brain, cervical and breast cancers. Folate is involved in the synthesis, repair, and functioning of DNA, our genetic map, and a deficiency of folate may result in damage to DNA that may lead to cancer. Folate is important for cells and tissues that rapidly divide.
Because folic acid is often deficient in those who are depressed, a supplement may help. Vitamin B9 (folate) may be associated with depression more than any other nutrient, and may play a role in the high incidence of depression in the elderly.
Folate deficiency appears to be linked to cervical dysplasia. Experts recommend getting adequate amounts of folate in the diet for all wome, which may be particularly important for those with risk factors for cervical dysplasia such as an abnormal pap smear or genital warts.
Vitamin B12’s main functions are in the formation of red blood cells and the maintenence of a healthy nervous system. Vitamin B12 is an especially important vitamin for maintaining healthy nerve cells and it aids in the production of DNA and RNA, the body’s genetic material. Cyanocobalamin works to promote normal growth and development, helps with certain types of nerve damage, and treats pernicious anemia. Vitamin B12 helps in the formation of red blood cells and in the maintenance of the central nervous system. Nerves are surrounded by an insulating fatty sheath comprised of a complex protein called myelin. B12 plays a vital role in the metabolism of fatty acids essential for the maintainence of myelin. Prolonged B12 deficiency can lead to nerve degeneration and irreversible neurological damage.
Vitamin B12 is essential for the proper production of blood platelets and red and white blood cells, the manufacture of vital substances needed for cell function, and the metabolism of nutrients necessary for cell growth. It participates in a variety of cellular reactions to release energy from carbohydrates, fats and protein. Vitamin B12 helps maintain the myelin sheath that insulates nerve fibres from each other. People with vitamin B12 deficiency show irregular destruction of the myelin sheaths, which eventually causes paralysis and death. Vitamin B12 levels decrease with age and various measures of cognitive impairment are associated with reduced B12 status. The most important use of vitamin B12 is to treat the symptoms of pernicious anemia.
Vitamin B9 (folate) and vitamin B12 are critical to the health of the nervous system and to a process that clears homocysteine from the blood. Vitamins B12, B6, and B9 (folate) work closely together to control blood levels of the amino acid homocysteine. Elevated plasma homocysteine concentrations are considered to be a risk factor for vascular disease and birth defects such as neural tube defects.
Vitamin PP (vitamin B3)
Niacin and niacinamide are the two main forms of vitamin B3. Both substances are key in releasing energy from carbohydrates, processing alcohol, forming fats, and producing sex hormones. A significant benefit of niacin is its ability to prevent recurrent heart attack. Niacin also helps regulate cholesterol levels. A third form of niacin, inositol hexaniacinate, is gaining acceptance as a substitute for niacin. Inositol hexaniacinate is composed of one molecule of inositol (an «unofficial» B vitamin) and six molecules of niacin.
Vitamin PP is used in diseases of the heart and liver, stomach ulcers and 12 duodenal ulcer, enterocolitis, weak healing ulcers and wounds, infectiousdiseases.
There is evidence of the effectiveness of vitamin РР in combination with vitamin E in the treatment of mild forms of diabetes. Vitamin PP also provides an effective action for the treatment of alcoholism and drug psychoses. Its deficiency leads to development of dermatitis and symptoms indicating a violation of the nervous system and gastrointestinal tract: nausea, loss of appetite, discomfort in the stomach, severe weakness, memory impairment.
Vitamin H (Vitamin В7)
The primary role of biotin is in the metabolism of fats, proteins and carbohydrates. Biotin functions as a critical component of several enzymes (where it functions as a coenzyme) involved in energy metabolism.
Biotin helps in the synthesis of fatty acids, in energy metabolism, and in the synthesis of amino acids and glucose. Biotin is also involved in making glucose, some amino acids and in energy production. Vitamin H plays a special role in enabling the body to use blood sugar (glucose), a major source of energy for body fluids.
Biotin supplements may improve thin, splitting, or brittle toe and fingernails as well as hair health. Biotin has also been used to combat alopecia (partial or complete loss of hair) in both children and adults. Biotin is typically included in most multi-vitamin supplements.
Biotin supplements are sometimes given to help reduce blood sugar in diabetic patients. People with type 2 diabetes often have low levels of biotin. The major benefit of biotin as a dietary supplement is in strengthening hair and nails. Biotin supplements may improve thin or splitting toenails or fingernails and improve hair health. Some skin disorders, such as «cradle cap,» improve with biotin supplements.
Biotin has also been used to combat premature graying of hair, though it is likely to be useful only for those with a low biotin level. Biotin has been used for people in weight loss programs to help them metabolize fat more efficiently.
Calcium are important for the proper formation of bones and muscles. To activate the calcium in bone tissue requires vitamin D, phosphate, magnesium, zinc, manganese, ascorbic acid, and other factors. Calcium reduces the manifestations of allergic reactions, pain syndromes and inflammatory processes. It is a factor in blood clotting. Lowers blood cholesterol. Participates in the formation of an immune response. Inadequate intake of calcium in the body increases the excretion of calcium from the bones into the bloodstream, causing bone demineralization and osteoporosis.
Significantly increases the need for it in pregnant and lactating women. Apply for the prevention of osteoporosis, regulation of the functioning of the CNS, the lack of parathyroid function, allergic diseases (serum sickness, urticaria, angioedema, hay fever), to reduce vascular permeability (hemorrhagic vasculitis, the phenomenon of radiation sickness, and exudative inflammatory processes), with skin diseases (eczema, psoriasis), chronic hepatitis, toxic liver damage, as a styptic for bleeding, as an antidote to poisoning by salts of oxalic acid and fluoride. Studies have shown that calcium, particularly in combination with vitamin D, may help prevent bone loss associated with menopause. It may also help prevent bone loss in older men.
According to the US National Institute of Health, magnesium is need for more than 300 biochemical processes in the body. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, supports a healthy immune system, and keeps bones strong. Magnesium also helps regulate blood sugar levels, promotes normal blood pressure, and is known to be involved in energy metabolism and protein synthesis. There is increased recognition of the role of magnesium in preventing and managing disorders such as hypertension, cardiovascular disease, and diabetes.
Magnesium has a cardioprotective effect, providing a beneficial effect on heart rhythm disturbances, coronary heart disease, myocardial infarction, improving myocardial oxygen supply. At the same time, magnesium exhibits vasodilator effect and helps reduce blood pressure. Magnesium is an anti-stress macro-elements, has a normalizing effect on the nervous system and its higher parts (especially in combination with vitamin B6) with nervous tension, depression, neurosis.
Magnesium in diabetes prevents cardiovascular complications and, in combination with zinc, chromium, selenium improves the function of beta cells of the pancreas. In diseases of the respiratory system enhances the removal of the bronchi and bronchospasm. In both cases, magnesium is an important factor in therapy (in combination with fixed assets).
Magnesium has a positive impact on the reproductive system. In pregnant women, magnesium deficiency prevents the development of the fruit (along with folic and pantothenic acid), the development of gestosis, premature births and miscarriages. At the time of menopause in women reduces the negative manifestations of this condition.